Obesity is a condition in which the body gains weight beyond normal limits due tothe accumulation of excess fat in the body. The use of inappropriate drugs withoutmedical supervision can be dangerous, so it is necessary to develop drugs using natural ingredients. 80% of the world's population use traditional systems of medicine as their first line of treatment. Bitter melon plant (Momordica charantia L) contains charantin, polypeptide-p, momordin, and oleanolic acid 3- omonodesmoside has hypoglycaemic activity and can lose weight. The aim of this study was to determine the efficacy of bitter melon (Momordica charantia L.) leaf infusion on weight loss in obese mice at test doses of 2000 mg and 4000 mg/kgB using the infusion method. The animals were fattened on a high-fat diet for 21days to achieve a body weight gain of >20% and then continued on the bitter melon leaf infusion for 14 days. The data obtained were statistically tested using the SPSS programme with Kruskal Wallis followed by the post hoc test. The results obtained showed that the comparison of the positive group with test dose 2had a p-value = 0.282, which means that there was no significant difference in weight change because the p-value > 0.05. Conclusion: Test dose 2 is a dose that can be used to lose weight because it can match the positive tail group given the drug orlistat.
Keyword : Bitter Melon Leaf (momodica Charantia L.), Antiobesity, Infusa,