Cuts are injuries that often occur due to several factors in everyday life. Cut wounds can be caused by sharp object trauma such as kitchen knives, broken glass or zinc which causes damage to body tissue. This study aims to determine whether the 70% ethanol extract of cherry stem bark (Muntingia calabura .L) has activity in accelerating the healing process of cuts in vivo. Kersen is a plant that is widely found in Indonesia and contains antioxidants. No one has used and cultivated it as a food crop. Several studies have shown that cherry stems contain antioxidant compounds such as tannins, triterpenes, saponins, alkaloids, polyphenols, and flavonoid compounds such as aurons, flavones and flavones which can be used as antimicrobials, antioxidants, antibacterials and antifungals, these compounds also function as antioxidants which can reduce free radicals. The research method was carried out experimentally using test animals, namely male mice (Mus musculus). The number of test animals used was 25 mice which were divided into 5 groups, namely the positive control group (10% betadine ointment), negative control (base ointment), extract concentrations of 10%, 20%, 30%. Mice in each group were anesthetized using phenobarbital (IP), then cuts were made with a length of 10 mm and a depth of 2 mm, then smeared once a day on the backs of mice as much as ± 0.1 gram in each group. Observations were made for 10 days by measuring the proportion of wound healing. The results of the proportion of wound healing were analyzed using SPPS 26. The results showed that the ethanol extract of 70% cherry stem bark with pharmacological tests had activity towards accelerating wound healing with weak activity and statistically the test was not significant with a p value <0.05. The optimal dose concentration of 70% cherry stem bark ethanol extract was not shown at a concentration of 10%, 20%, or 30%.
Keyword : Cut Wounds, Cherry Stem Bark, Extract 70% Cherry Stem Bark, Wound Healing, Male White,