Susenas results (2018) noted that 31.59% of children aged 0-17 years experienced health complaints, as many as 32.89% of children experienced health complaints in urban areas and 30.10% in rural areas. Concoction prescriptions are drug preparations that are widely used by doctors in prescribing drugs for pediatric patients. Concoction recipes are an option because doctors can freely combine several active substances in one preparation to overcome the limitations of finished preparations that do not contain the desired active substance. Polypharmacy is one of the problems in prescribing concoctions, because the more combinations of drugs, the higher the potential for drug interactions. This study analyzed data on concoction recipes that had been collected based on inclusion and exclusion criteria using an analytic descriptive retrospective method. The data was processed using tabulations in Microsoft Excel after the data was identified using drugbank (drug interaction checker) to analyze pharmacokinetic and pharmacodynamic drug interactions and using leaflets, supporting journals and the 3rd edition of the Indonesian Pharmacopoeia to analyze pharmaceutical interactions. The results showed that the incidence of drug interactions in pharmacokinetics was 6.7%, pharmacodynamics was 28.3% and pharmaceuticals based on inappropriate dosage forms were 8.3% and based on pharmaceutical conventions were 11.6%. It can be concluded that there is a potential for drug interactions pharmacokinetic, pharmacodynamic and pharmaceutical in the prescription of pulveres concoction in pediatric patients.
Keyword : Pediatrics, Pulveres, Interaction Potential, Severity Level,